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ATCC
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Kamei Co Ltd
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European Collection of Authenticated Cell Cultures
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Arkat USA Inc
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Dainippon Sumitomo
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Verlag GmbH
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Armatis GmbH
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Varian Medical
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Image Search Results
Journal: Antibody Therapeutics
Article Title: Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody–drug conjugate
doi: 10.1093/abt/tbaf006
Figure Lengend Snippet: Binding of BA3011 to cell-surface expressed AXL analyzed by flow cytometry. (A) Concentration-dependent binding of BA3011 to human (top left panel) or cynomolgus AXL (top right panel) expressed on the surface of 293-F cells and cancer cell lines DU145 (bottom left panel) and LCLC103H (bottom right at pH 6.0 (solid line) and pH 7.4 (dashed line). (B) The table shows the EC 50 values at pH6.0 calculated from the binding curves shown in (A). No meaningful EC 50 could be calculated at pH 7.4.
Article Snippet: The antitumor activity of BA3011 was assessed using different cell line-derived xenograft (CDX) models, including the LCLC-103H large cell lung carcinoma cell line (performed at Crown Bioscience), the
Techniques: Binding Assay, Flow Cytometry, Concentration Assay
Journal: Antibody Therapeutics
Article Title: Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody–drug conjugate
doi: 10.1093/abt/tbaf006
Figure Lengend Snippet: BA3011 in vitro cytotoxicity assay. BA3011 in vitro cell killing of LCLC103H cells (A), DU145 cells (B), or AXL-negative 293-F cells (C) at pH 6.0 (solid lines) and pH 7.4 (dashed lines). Ctrl: B12-MMAE. (D) IC 50 values calculated from the inhibition curves from three independent experiments.
Article Snippet: The antitumor activity of BA3011 was assessed using different cell line-derived xenograft (CDX) models, including the LCLC-103H large cell lung carcinoma cell line (performed at Crown Bioscience), the
Techniques: In Vitro, Cytotoxicity Assay, Inhibition
Journal: Antibody Therapeutics
Article Title: Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody–drug conjugate
doi: 10.1093/abt/tbaf006
Figure Lengend Snippet: In vivo cytotoxicity of BA3011. Cytotoxicity of BA3011 was tested in several cell-line derived tumor models in mice: (A) LCLC103H (lung cancer); (B) MiaPaCa (pancreatic cancer), and (C) DU145 (prostate cancer). Animals were dosed every 4 days (arrows) intravenously with BA3011 or buffer only (vehicle) at the concentrations indicated in the graph.
Article Snippet: The antitumor activity of BA3011 was assessed using different cell line-derived xenograft (CDX) models, including the LCLC-103H large cell lung carcinoma cell line (performed at Crown Bioscience), the
Techniques: In Vivo, Derivative Assay